Tear Glucose Sensor Development

Clinical Evidence for Use of a Noninvasive Biosensor for Tear Glucose as an Alternative to Painful Finger-Prick for Diabetes Management Utilizing a Biopolymer Coating

Alicja E. Kownacka, Dovile Vegelyte, Maurits Joosse, Nicoleta Anton, B. Jelle Toebes, Jan Lauko, Irene Buzzacchera, Katarzyna Lipinska, Daniela A. Wilson, Nel Geelhoed-Duijvestijn, and Christopher J. Wilson

ABSTRACT: Diabetes is a metabolic condition that is exponentially increasing worldwide. Current monitoring methods for diabetes are invasive, painful, and expensive. Herein, we present the first multipatient clinical trial that demonstrates clearly that tear fluid may be a valuable marker for systemic glucose measurements. The NovioSense Glucose Sensor, worn under the lower eye lid (inferior conjunctival fornix), is reported to continuously measure glucose levels in the basal tear fluid with good correlation to blood glucose values, showing clear clinical feasibility in both animals and humans. Furthermore, the polysaccharide coated device previously reported by our laboratory when worn, does not induce pain or irritation. In a phase II clinical trial, six patients with type 1 Diabetes Mellitus were enrolled and the capability of the device to measure glucose in the tear fluid was evaluated. The NovioSense Glucose Sensor gives a stable signal and the results correlate well to blood glucose values obtained from finger-prick measurements determined by consensus error grid analysis.


Polymer Brush-Functionalized Chitosan Hydrogels as Antifouling Implant Coatings

Irene Buzzacchera, Mariia Vorobii, Nina Yu. Kostina, Andres de los Santos Pereira, TomasĚ